Trihalomethanes as initiators and promoters of carcinogenesis.
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منابع مشابه
Trihalomethanes as initiators and promoters of carcinogenesis.
Chloroform and other trihalomethanes are contaminants of drinking water that have been demonstrated to be carcinogenic in laboratory animals. Determination of the mechanism of carcinogenicity of chloroform is required so that the animal data can be extrapolated to estimate the human health hazard. The extent of the binding of chloroform to rat liver and kidney DNA was approximately 0.1% the lev...
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A cell line (HRRT) derived from a hereditary renal rat tumor has been used in an assay for initiators and promoters of carcinogenesis based on attachment-independent survival in aggregates. Treatment with single noncytotoxic doses of the carcinogens urethan (1 mM), N-methyl-N-nitrosourea (30 microM), and benzo(a)pyrene (0.2 microM) for 1 hr did not affect survival of HRRT cells in the aggregate...
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Hormones, particularly ovarian steroids and pituitary prolactin, promote mammary carcinogenesis in rats treated with a carcinogen. Hormones also play a critical role during the initiation process as demonstrated by mammary carcinogenesis in ovariectomized rats. A diet high in fat content, especially polyunsaturated fat, promotes mammary tumorigenesis when it is fed to carcinogen-treated rats fo...
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On the other hand, the less stabilized tris(4chlorophenyl)methyl cation (1 b) was reported to initiate the polymerization of isobutene3). In accordance, p-methoxy and p-methyl substituted tritylium ions do not initiate the polymerization of a-methylstyrene, in contrast to the less stable 1 a and 1 b4). Only for few reactive monomers, however, the initiation was proven to proceed via addition of...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1982
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.8246151